1. The robot worked fine until it tried to maneuver around the corner and went haywire. Its arms started to spin around, its head fell off, and it started shooting sparks out of its control panel.
2. When the man heard that his doctor’s appointment was cancelled, he went haywire. He shouted that he would never go to the doctor again, and left.

Similar to: at the end of (one’s) rope; go bananas; at (one’s) wits’ end; go to pieces. Go haywire is generally applied to machines, whereas go bananas is more humorous and is restricted to people.