1. I don’t like that man. Perhaps it’s the way he talks to me or the way he acts around us—he sure gets my dander up.
2. Our neighbors are extremely messy and loud. They get my hackles up.

Synonyms: rub (someone) the wrong way; set (someone’s) teeth on edge; get (someone’s) goat; bug. Whereas bug means to annoy harmlessly or perhaps humorously, get one’s dander up means to irritate in earnest.